5-HTP (5-hydroxytryptophan)

5-HTP (5-hydroxytryptophan) is a natural substance that is produced in your body from the amino acid L-tryptophan. This compound is mainly known as an intermediate step in the production of serotonin, an important neurotransmitter that plays a role in your mood, sleep, appetite and general state of mind.

5-HTP is often used as a dietary supplement because it can help your body maintain healthy serotonin levels, which in turn can contribute to better balance in how you feel, sleep, and function.

Where does 5-HTP come from?

5-HTP occurs naturally in your body as an intermediate product when L-tryptophan, an essential amino acid in your diet, is converted to 5-HTP and then to serotonin. In practice, however, 5-HTP is most often extracted from the seeds of the African plant Griffonia simplicifolia.

The seeds of Griffonia simplicifolia naturally contain a relatively high concentration of 5-HTP, making them a valuable source for extraction and processing into powder or capsule form.

The use of this plant source makes it possible to obtain a standardized and reliable supplement, which can then be used safely and in a controlled manner for personal use.

What is 5-HTP good for?

5-HTP, extracted from the seeds of the African plant Griffonia simplicifolia, is primarily associated with supporting your nervous system and mood. For example, 5-HTP can play a role in the normal functioning of your nerves and nervous system, and have an uplifting effect when you are feeling less cheerful or experiencing ups and downs in your mood.

5-HTP contributes to:

• The normal functioning of the nervous system and nerves.*
• An uplifting effect on depressed, gloomy or melancholic feelings.*
• Supporting you through ups and downs in mood.*

*Health claim pending European approval.

Does 5-HTP have side effects?

Although 5-HTP is generally well tolerated, there are possible side effects you may experience, such as nausea, stomach cramps, and in very rare cases, diarrhea or vomiting.

These complaints arise because part of the 5-HTP you take can be converted into serotonin in your peripheral nervous system, before it reaches the brain. This can temporarily cause too much serotonin locally, which can cause irritation of the gastrointestinal tract.

Fortunately, these side effects are only temporary. If you build up 5-HTP carefully and possibly spread it out over the day, these symptoms often disappear on their own.

Contraindications of 5-HTP

While 5-HTP may be an interesting option for many people to support their serotonin balance, there are certain situations in which its use is not recommended.

For example, it is generally not recommended to use 5-HTP during pregnancy or breastfeeding, because there is insufficient data available on its safety for you and your child. In addition, there are indications that supplementation with 5-HTP can lead to unpredictable effects for people with Down syndrome.

It is also wise to be careful when using certain medications. In particular, drugs that affect brain metabolism, such as certain antidepressants, tranquilizers or anti-anxiety drugs, may have an adverse interaction with 5-HTP. By consulting an expert in these cases, you can ensure that you make responsible choices and put your health first.

How much 5-HTP per day?

The general recommended dosage for 5-HTP is between 50 and 300 mg per day. It is advisable to gradually build up the intake of 5-HTP, so that your body has the chance to adapt and minimize any side effects.

By dividing the total daily amount into smaller portions and taking them with meals, you can ensure a more even release and support your serotonin balance.

How long can you use 5-HTP?

In general, it is recommended to use 5-HTP over a period of several weeks to months, depending on your personal needs and circumstances.

For long-term use, it is wise to regularly evaluate how you feel and, if necessary, consult an expert. This way, you can continue to benefit responsibly from the potential benefits that 5-HTP has to offer.